No matter what shade of red your Valentine’s Day was last month—sultry or sullen, sad or sweet—your heart beat more than 100,000 times, pumping 7500 liters of blood. Designing a device to achieve such precision and maintain it over a lifetime (about 70 years) requires integration of biology and engineering at a staggering level. Understandably then, despite great progress, design of adaptable, living heart valves has not been achieved. Prosthetic valves, for example, are nonliving structures that lack the functionality to respond to dynamic blood flow across days and years or the ability to grow with younger patients. Bouten and colleagues tackled this challenge with a fully synthetic heart valve designed from slowly degrading polymer that utilizes structural features to promote colonization by host cells, allowing the synthetic valve to be slowly replaced by functional tissue.
Kategoria: Cardiovascular science
From 1’st-3’rd of of May I had a chance to take part in 3D Challenge at Texas A&M Qatar, where I presented the principles of my project concerning 3D-printed heart valve scaffolds. The project’s presentation was distinguished for its scientific value and received a first place award.
Following materials consist of my current work related to design of heart valve scaffolds. If you are interested in collaborating with me, you can read presented documents, to make yourself acquainted with the scope of my research.
3D model of heart valve woven scaffold’s performance during blood flow.
The performance of sheep’s heart valve working externally.
Bacterial bionanocellulose for heart valve tissue engineering – current status, progress and perspectives
- Developing 3D geometry of entire valve using controlled deposition of cellulose on the mandrel.
My plan is to cultivate the bacteria in such way, that at the end a readily heart valve will be obtained. The growth medium (or one of its constituents) should be formed appropriately. The bacteria will than produce cellulose, but only in the provided shape.
Advanced geometrical Ca- alginate structures were already obtained by me in similar manner (fig.1.).
The Qatar Foundation Annual Research Conference 2016 (ARC’16) was held on 22nd and 23rd March 2016 at the Qatar National Convention Centre.
On the conference we presented 6 posters concerning heart valve scaffolds. All the posters can be found below.
The results of following survey were presented at Qatar Foundation Annual Research Conference 2016 (ARC’16) 22nd-23rd March 2016, Qatar National Convention Centre, Doha, Qatar
The first task of tissue engineer trying to make a scaffold of a heart valve, is to adapt some model of a heart valve to establish target geometries and properties that should be recreated in artificial scaffold. The natural way to do so is to conduct literature research and find the current scientific consensus on the topic. Here the problems start, each researcher seems to have an individual opinion about optimal geometry of valve. What makes situation more complex is that each researcher has carefully chosen arguments to explain why that particular design is better than others. Hence, the consensus is not there yet, we chosen to contribute to this discussion. The analysis of available reports enable to “cook out” 2 distinguishable and to some extent contrary hypothesis.
1st –the optimal architecture of artificial valve is an architecture of native one (Prof. Magdi Yacoub).
2nd-there is not such a thing as optimal architecture of a heart valve, and never will be