Knitting is a versatile technology which offers a large portfolio of products and solutions that are of interest in heart valve (HV) tissue engineering (TE). One of the main advantages of knitting is its ability to construct complex shapes and structures by precisely assembling the yarns in the desired position. With this in mind, knitting could be employed to construct a HV scaffold that closely resembles the authentic valve. This has the potential to reproduce the anisotropic structure that is characteristic of the heart valve with the yarns, in particular the 3-layered architecture of the leaflets. These yarns can provide oriented growth of cells in a lengthwise direction and consequently enable the deposition of extracellular matrix (ECM) proteins in an oriented manner. This technique, therefore, has a potential to provide a functional knitted scaffold, but to achieve that textile engineers need to gain a basic understanding of structural and mechanical aspects of the heart valve and in addition, tissue engineers must acquire the knowledge of tools and capacities that are essential in knitting technology. The aim of this review is to provide a platform to consolidate these two fields as well as to enable an efficient communication and cooperation among these two research areas. Dear Readers. In case of misunderstanding regarding the publisher of this paper, we would like to inform that the paper was submitted to Global Cardiology Science and Practice, published by QScience. Nevertheless the publisher informed that they are suspending their publishing and recommended moving the paper to another journal. Without noticing us about it, the paper was however published in different journal with the same name. Because of that the paper could appear in two journals, which was not our aim and we as authors are not responsible for this situation. It is a matter to be solved between the two publishers.

Weaving is a resourceful technology which offers a large selection of solutions that are readily adaptable for tissue engineering (TE) of artificial heart valves (HV). The different ways that the yarns are interlaced in this technique could be used to produce complex architectures, such as the three-layer architecture of the leaflets. Once the assembly is complete, growth of cells in the scaffold would occur in the orientation of the yarn, enabling the deposition of extra cellular matrixes proteins in an oriented manner. Weaving technology is a rapidly evolving field that, first, needs to be understood, and then explored by tissue engineers, so that it could be used to create efficient scaffolds. Similarly, the textile engineers need to gain a basic understanding of key structural and mechanical aspects of the heart valve. The aim of this review is to provide the platform for joining these two fields and to enable cooperative research efforts. Moreover, examples of woven medical products and patents as well as related publication are discussed in this review, nevertheless due to the large, and continuously growing volume of data, only the aspects strictly associated with HVTE lay in the scope of this paper.

Three-dimensional (3D) printing is a resourceful technology that offers a large selection of solutions that are readily adaptable to tissue engineering of artificial heart valves (HVs). Different deposition techniques could be used to produce complex architectures, such as the three-layered architecture of leaflets. Once the assembly is complete, the growth of cells in the scaffold would enable the deposition of cell-specific extracellular matrix proteins. 3D printing technology is a rapidly evolving field that first needs to be understood and then explored by tissue engineers, so that it could be used to create efficient scaffolds. On the other hand, to print the HV scaffold, a basic understanding of the fundamental structural and mechanical aspects of the HV should be gained. This review is focused on alginate that can be used as a building material due to its unique properties confirmed by the successful application of alginate-based biomaterials for the treatment of myocardial infarction in humans.

Alginate is a versatile and adaptable biomaterial that has found numerous biomedical applications which include wound healing, drug delivery and tissue engineering. Due to its biologically favorable properties including the ease of gelation and its biocompatibility, alginate-based hydrogels have been considered a particularly attractive material for the application in cardiac regeneration and valve replacement techniques. Here, we review current applications of alginate in cardiac regeneration as well as perspectives for the alginate-dependent, cardiac regeneration strategies. Dear Readers. In case of misunderstanding regarding the publisher of this paper, we would like to inform that the paper was submitted to Global Cardiology Science and Practice, published by QScience. Nevertheless the publisher informed that they are suspending their publishing and recommended moving the paper to another journal. Without noticing us about it, the paper was however published in different journal with the same name. Because of that the paper could appear in two journals, which was not our aim and we as authors are not responsible for this situation. It is a matter to be solved between the two publishers.